7.88J / 5.48J / 7.24J / 10.543J Protein Folding Problem, Fall 2003
Name
7-88JFall-2003/OcwWeb/Biology/7-88JProtein-Folding-ProblemFall2003/CourseHome/index.htm
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14.65 KB
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Checksum (MD5)
cf3098c764177101f3993597ec4208d6
Author(s)
King, Jonathan, 1941-
Gossard, D.
Alternative Title
Protein Folding Problem
Date Issued
December 2003
Abstract
Mechanisms by which the amino acid sequence of polypeptide chains determines their three-dimensional conformation. Topics include: sequence determinants of secondary structure; folding of newly synthesized polypeptide chains within cells; unfolding and refolding of proteins in vitro; folding intermediates aggregation and competing off-pathway reactions; role of chaperonins, isomerases, and other helper proteins; protein recovery problems in the biotechnology industry; diseases associated with protein folding defects.
Subjects
amino acid sequence
polypeptide chains
sequence determinants
synthesized polypeptide chains within cells
competing off-pathway reactions
chaperonins
isomerases
helper proteins
protein recovery problems
biotechnology industry
protein folding defects
3-D conformation
globular proteins
fibrous proteins
kinetics
in vitro refolding
pathways
in vivo folding
synthesized proteins
aggregation
protein misfolding
human disease
protein folding
genome sequences
7.88J
5.48J
7.24J
10.543J
7.88
5.48
7.24
10.543
MIT Department
Massachusetts Institute of Technology. Department of Biology
Massachusetts Institute of Technology. Department of Chemical Engineering
Massachusetts Institute of Technology. Department of Chemistry
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