Metabolic Tumor Profiling with pH, Oxygen, and Glucose Chemosensors on a Quantum Dot Scaffold
Name
Bawendi_Metabolic tumor.pdf
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1.8 MB
Format
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Author(s)
Lemon, Christopher M.
Curtin, Peter N.
Somers, Rebecca C.
Greytak, Andrew B.
Lanning, Ryan M.
Jain, Rakesh K.
Bawendi, Moungi G.
Nocera, Daniel G.
Date Issued
October 2013
Journal
Inorganic Chemistry
Publisher
American Chemical Society (ACS)
Citation
Lemon, Christopher M., Peter N. Curtin, Rebecca C. Somers, Andrew B. Greytak, Ryan M. Lanning, Rakesh K. Jain, Moungi G. Bawendi, and Daniel G. Nocera. “Metabolic Tumor Profiling with pH, Oxygen, and Glucose Chemosensors on a Quantum Dot Scaffold.” Inorg. Chem. 53, no. 4 (February 17, 2014): 1900–1915.
Version
Author's final manuscript
Abstract
Acidity, hypoxia, and glucose levels characterize the tumor microenvironment rendering pH, pO2, and pGlucose, respectively, important indicators of tumor health. To this end, understanding how these parameters change can be a powerful tool for the development of novel and effective therapeutics. We have designed optical chemosensors that feature a quantum dot and an analyte-responsive dye. These noninvasive chemosensors permit pH, oxygen, and glucose to be monitored dynamically within the tumor microenvironment by using multiphoton imaging.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
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Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1021/ic401587r
