Drug Delivery Interfaces in the 21st Century: From Science Fiction Ideas to Viable Technologies
Name
nihms514827.pdf
Description
Accepted version
Size
1.8 MB
Format
Adobe PDF
Checksum (MD5)
2bd134e7f65041e41839ddc9bbfe4604
Author(s)
Chertok, Beata
Webber, Matthew J.
Succi, Marc D.
Langer, Robert S
Date Issued
August 2013
Journal
Molecular Pharmaceutics
Publisher
American Chemical Society (ACS)
Citation
Chertok, Beata, et al. “Drug Delivery Interfaces in the 21st Century: From Science Fiction Ideas to Viable Technologies.” Molecular Pharmaceutics 10, 10 (October 2013): 3531–43.
Version
Author's final manuscript
Abstract
Early science fiction envisioned the future of drug delivery as targeted micrometer-scale submarines and "cyborg" body parts. Here we describe the progression of the field toward technologies that are now beginning to capture aspects of this early vision. Specifically, we focus on the two most prominent types of systems in drug delivery: the intravascular micro/nano drug carriers for delivery to the site of pathology and drug-loaded implantable devices that facilitate release with the predefined kinetics or in response to a specific cue. We discuss the unmet clinical needs that inspire these designs, the physiological factors that pose difficult challenges for their realization, and viable technologies that promise robust solutions. We also offer a perspective on where drug delivery may be in the next 50 years based on expected advances in material engineering and in the context of future diagnostics. Keywords: drug delivery; drug carriers; nanotechnology; controlled release implants; physiological barriers; pharmacokinetics; translational medicine
MIT Department
Massachusetts Institute of Technology. Department of Chemical Engineering
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1021/MP4003283
