Pluripotency and Cellular Reprogramming: Facts, Hypotheses, Unresolved Issues
Name
Hanna-2010-Pluripotency and Cel.pdf
Size
1.35 MB
Format
Adobe PDF
Checksum (MD5)
27f2a19a16a7cdbcee1112872c46e239
Author(s)
Hanna, Jacob
Saha, Krishanu
Jaenisch, Rudolf
Date Issued
November 2010
Journal
Cell
Publisher
Elsevier B.V.
Citation
Hanna, Jacob H., Krishanu Saha, and Rudolf Jaenisch. “Pluripotency and Cellular Reprogramming: Facts, Hypotheses, Unresolved Issues.” Cell 143, no. 4 (November 2010): 508–525. © 2010 Elsevier Inc.
Version
Final published version
Abstract
Direct reprogramming of somatic cells to induced pluripotent stem cells by ectopic expression of defined transcription factors has raised fundamental questions regarding the epigenetic stability of the differentiated cell state. In addition, evidence has accumulated that distinct states of pluripotency can interconvert through the modulation of both cell-intrinsic and exogenous factors. To fully realize the potential of in vitro reprogrammed cells, we need to understand the molecular and epigenetic determinants that convert one cell type into another. Here we review recent advances in this rapidly moving field and emphasize unresolved and controversial questions.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Whitehead Institute for Biomedical Research
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/j.cell.2010.10.008
