p63 and p73 Transcriptionally Regulate Genes Involved in DNA Repair
Name
Lin-2009-p63 and p73 Transcriptionally Regulate Genes Involved in DNA Repair.pdf
Size
709.16 KB
Format
Adobe PDF
Checksum (MD5)
ce8594291a8081a0c4e76782590fac8f
Author(s)
Lin, Yu-Li
Sengupta, Shomit
Gurdziel, Katherine
Bell, George W.
Flores, Elsa R.
Jacks, Tyler E
Date Issued
October 2009
Journal
PLoS Genetics
Publisher
Public Library of Science
Citation
Lin Y-L, Sengupta S, Gurdziel K, Bell GW, Jacks T, et al. (2009) p63 and p73 Transcriptionally Regulate Genes Involved in DNA Repair. PLoS Genet 5(10): e1000680. doi:10.1371/journal.pgen.1000680
Version
Final published version
Abstract
The p53 family activates many of the same genes in response to DNA damage. Because p63 and p73 have structural differences from p53 and play distinct biological functions in development and metastasis, it is likely that they activate a unique transcriptional network. Therefore, we performed a genome-wide analysis using cells lacking the p53 family members after treatment with DNA damage. We identified over 100 genes involved in multiple pathways that were uniquely regulated by p63 or p73, and not p53. Further validation indicated that BRCA2, Rad51, and mre11 are direct transcriptional targets of p63 and p73. Additionally, cells deficient for p63 and p73 are impaired in DNA repair and p63+/−;p73+/− mice develop mammary tumors suggesting a novel mechanism whereby p63 and p73 suppress tumorigenesis.
MIT Department
Broad Institute of MIT and Harvard
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution
Persistent DSpace Link
DOI of Published Version
http://dx.doi.org/10.1371/journal.pgen.1000680
