Toll Like receptor 7 regulates viral loads and cytokine secretion during acute retroviral infection

Browne, Edward P.

Toll Like receptor 7 regulates viral loads and cytokine secretion during acute retroviral infection

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Browne-2012-Toll Like receptor 7 regulates viral loads and cytokine secretion during acute retroviral infection.pdf

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Author(s)

Browne, Edward P.

Date Issued

September 2012

Journal

Retrovirology

Publisher

Biomed Central Ltd.

Citation

Browne, Edward P. "Toll Like receptor 7 regulates viral loads and cytokine secretion during acute retroviral infection." Retrovirology 9.Suppl 2 (2012): 174.

Version

Final published version

Abstract

Background: Acute HIV infection is characterized by a high viremia accompanied by a powerful wave of pro-inflammatory cytokines that affects the subsequent course of infection and pathogenesis. Thus, understanding the mechanisms that regulate cytokine secretion and viremia is a key priority. The innate immune receptor TLR7 has been identified a retrovirus-sensing protein, and is expressed in several key immune lineages. In vitro data suggests that HIV can trigger TLR7-dependent innate immune responses, but TLR7s role in vivo is unclear.

MIT Department

Koch Institute for Integrative Cancer Research at MIT

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http://creativecommons.org/licenses/by/2.0

Persistent DSpace Link

http://hdl.handle.net/1721.1/76702

DOI of Published Version

http://www.retrovirology.com/content/9/S2/P174