Predicting specificity in bZIP coiled-coil protein interactions
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13059_2003_Article_815.pdf
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457.39 KB
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Author(s)
Singh, Mona
Keating, Amy E.
Fong, Jessica H.
Date Issued
January 2004
Journal
Genome Biology
Publisher
BioMed Central
Citation
Fong, Jessica H, Amy E Keating, and Mona Singh. "Predicting specificity in bZIP coiled-coil protein interactions." Genome Biology 5, no. 2 (2004): R11.
Version
Final published version
Abstract
We present a method for predicting protein-protein interactions mediated by the coiled-coil motif. When tested on interactions between nearly all human and yeast bZIP proteins, our method identifies 70% of strong interactions while maintaining that 92% of predictions are correct. Furthermore, cross-validation testing shows that including the bZIP experimental data significantly improves performance. Our method can be used to predict bZIP interactions in other genomes and is a promising approach for predicting coiled-coil interactions more generally.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Terms of Use
Creative Commons Attribution 4.0 International License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1186/gb-2004-5-2-r11
