TOWARD QUANTITATIVE OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY: Visualizing Blood Flow Speeds in Ocular Pathology Using Variable Interscan Time Analysis
Name
nihms808632.pdf
Description
Accepted version
Size
3.55 MB
Format
Adobe PDF
Checksum (MD5)
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Author(s)
Ploner, Stefan B
Moult, Eric Michael
Choi, WooJhon
Lee, ByungKun
Potsaid, Benjamin M.
Schottenhamml, Julia Jennifer
Fujimoto, James G
Alternative Title
Toward quantitative OCT angiography: visualizing blood flow speeds in ocular pathology using variable interscan time analysis (VISTA)
Date Issued
December 2016
Journal
Retina
Publisher
Ovid Technologies (Wolters Kluwer Health)
Citation
Ploner, Stefan B. et al. “Toward quantitative OCT angiography: visualizing blood flow speeds in ocular pathology using variable interscan time analysis (VISTA).” Retina, 36 (Suppl 1), 12 (December 2016): S118–S126 © 2016 The Author(s)
Version
Author's final manuscript
Abstract
Purpose: Currently available optical coherence tomography angiography systems provide information about blood flux but only limited information about blood flow speed. The authors develop a method for mapping the previously proposed variable interscan time analysis (VISTA) algorithm into a color display that encodes relative blood flow speed. Methods: Optical coherence tomography angiography was performed with a 1,050 nm, 400 kHz A-scan rate, swept source optical coherence tomography system using a 5 repeated B-scan protocol. Variable interscan time analysis was used to compute the optical coherence tomography angiography signal from B-scan pairs having 1.5 millisecond and 3.0 milliseconds interscan times. The resulting VISTA data were then mapped to a color space for display. Results: The authors evaluated the VISTA visualization algorithm in normal eyes (n = 2), nonproliferative diabetic retinopathy eyes (n = 6), proliferative diabetic retinopathy eyes (n = 3), geographic atrophy eyes (n = 4), and exudative age-related macular degeneration eyes (n = 2). All eyes showed blood flow speed variations, and all eyes with pathology showed abnormal blood flow speeds compared with controls. Conclusion: The authors developed a novel method for mapping VISTA into a color display, allowing visualization of relative blood flow speeds. The method was found useful, in a small case series, for visualizing blood flow speeds in a variety of ocular diseases and serves as a step toward quantitative optical coherence tomography angiography.
MIT Department
Massachusetts Institute of Technology. Research Laboratory of Electronics
Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
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DOI of Published Version
https://doi.org/10.1097/IAE.0000000000001328
