Rapid Wolff–Kishner reductions in a silicon carbide microreactor
Name
SG_Newan_Wolff-Kishner_Green_Chemistry.pdf
Size
671.54 KB
Format
Adobe PDF
Checksum (MD5)
21b615c90a804332abf945697d7da7c2
Author(s)
Newman, Stephen G.
Gu, Lei
Lesniak, Christoph
Victor, Georg
Meschke, Frank
Abahmane, Lahbib
Jensen, Klavs F.
Date Issued
2014
Journal
Green Chemistry
Publisher
Royal Society of Chemistry
Citation
Newman, Stephen G., Lei Gu, Christoph Lesniak, Georg Victor, Frank Meschke, Lahbib Abahmane, and Klavs F. Jensen. “Rapid Wolff–Kishner Reductions in a Silicon Carbide Microreactor.” Green Chemistry 16, no. 1 (2013): 176.
Version
Author's final manuscript
Abstract
Wolff–Kishner reductions are performed in a novel silicon carbide microreactor. Greatly reduced reaction times and safer operation are achieved, giving high yields without requiring a large excess of hydrazine. The corrosion resistance of silicon carbide avoids the problematic reactor compatibility issues that arise when Wolff–Kishner reductions are done in glass or stainless steel reactors. With only nitrogen gas and water as by-products, this opens the possibility of performing selective, large scale ketone reductions without the generation of hazardous waste streams.
MIT Department
Massachusetts Institute of Technology. Department of Chemical Engineering
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1039/c3gc41942h
