Sensing centromere tension: Aurora B and the regulation of kinetochore function
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Cheeseman_Sensing centromere.pdf
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134.31 KB
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Adobe PDF
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1bc73e89db9cb5e99fdc0be7eec62f49
Author(s)
Lampson, Michael A.
Cheeseman, Iain M
Date Issued
November 2010
Journal
Trends in Cell Biology
Publisher
Elsevier
Citation
Lampson, Michael A., and Iain M. Cheeseman. “Sensing Centromere Tension: Aurora B and the Regulation of Kinetochore Function.” Trends in Cell Biology 21, no. 3 (March 2011): 133–40.
Version
Author's final manuscript
Abstract
Maintaining genome integrity during cell division requires regulated interactions between chromosomes and spindle microtubules. To ensure that daughter cells inherit the correct chromosomes, the sister kinetochores must attach to opposite spindle poles. Tension across the centromere stabilizes correct attachments, whereas phosphorylation of kinetochore substrates by the conserved Ipl1/Aurora B kinase selectively eliminates incorrect attachments. Here, we review our current understanding of how mechanical forces acting on the kinetochore are linked to biochemical changes to control chromosome segregation. We discuss models for tension sensing and regulation of kinetochore function downstream of Aurora B, and mechanisms that specify Aurora B localization to the inner centromere and determine its interactions with substrates at distinct locations.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Whitehead Institute for Biomedical Research
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Creative Commons Attribution-Noncommercial-NoDerivatives
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DOI of Published Version
https://doi.org/10.1016/j.tcb.2010.10.007
