Defensins, lectins, mucins, and secretory immunoglobulin A: microbe-binding biomolecules that contribute to mucosal immunity in the human gut
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nihms820401.pdf
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2.18 MB
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Author(s)
Chairatana, Phoom
Nolan, Elizabeth Marie
Date Issued
November 2016
Journal
Critical Reviews in Biochemistry and Molecular Biology
Publisher
Informa UK Limited
Citation
Chairatana, Phoom, and Nolan, Elizabeth M. . “Defensins, Lectins, Mucins, and Secretory Immunoglobulin A: Microbe-Binding Biomolecules That Contribute to Mucosal Immunity in the Human Gut.” Critical Reviews in Biochemistry and Molecular Biology 52, 1 (November 2016): 45–56 © 2016 Informa UK Limited, trading as Taylor & Francis Group. Keywords: Mucosal immunity; Paneth cells; host defense; defensins; lectins; mucins; sIgA
Version
Author's final manuscript
Abstract
In the intestine, the mucosal immune system plays essential roles in maintaining homeostasis between the host and microorganisms, and protecting the host from pathogenic invaders. Epithelial cells produce and release a variety of biomolecules into the mucosa and lumen that contribute to immunity. In this review, we focus on a subset of these remarkable host-defense factors–enteric α-defensins, select lectins, mucins, and secretory immunoglobulin A–that have the capacity to bind microbes and thereby contribute to barrier function in the human gut. We provide an overview of the intestinal epithelium, describe specialized secretory cells named Paneth cells, and summarize our current understanding of the biophysical and functional properties of these select microbe-binding biomolecules. We intend for this compilation to complement prior reviews on intestinal host-defense factors, highlight recent advances in the field, and motivate investigations that further illuminate molecular mechanisms as well as the interplay between these molecules and microbes.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
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Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1080/10409238.2016.1243654
