Magneto-fluorescent core-shell supernanoparticles
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Jasanoff_Magneto-fluorescent.pdf
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1.72 MB
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Author(s)
Chen, Ou
Riedemann, Lars
Etoc, Fred
Herrmann, Hendrik
Coppey, Mathieu
Barch, Mariya
Farrar, Christian T.
Zhao, Jing
Wei, He
Guo, Peng
Date Issued
October 2014
Journal
Nature Communications
Publisher
Nature Publishing Group
Citation
Chen, Ou, Lars Riedemann, Fred Etoc, Hendrik Herrmann, Mathieu Coppey, Mariya Barch, Christian T. Farrar, et al. “Magneto-Fluorescent Core-Shell Supernanoparticles.” Nat Comms 5 (October 9, 2014): 5093.
Version
Author's final manuscript
Abstract
Magneto-fluorescent particles have been recognized as an emerging class of materials that exhibit great potential in advanced applications. However, synthesizing such magneto-fluorescent nanomaterials that simultaneously exhibit uniform and tunable sizes, high magnetic content loading, maximized fluorophore coverage at the surface and a versatile surface functionality has proven challenging. Here we report a simple approach for co-assembling magnetic nanoparticles with fluorescent quantum dots to form colloidal magneto-fluorescent supernanoparticles. Importantly, these supernanoparticles exhibit a superstructure consisting of a close-packed magnetic nanoparticle ‘core’, which is fully surrounded by a ‘shell’ of fluorescent quantum dots. A thin layer of silica coating provides high colloidal stability and biocompatibility, and a versatile surface functionality. We demonstrate that after surface pegylation, these silica-coated magneto-fluorescent supernanoparticles can be magnetically manipulated inside living cells while being optically tracked. Moreover, our silica-coated magneto-fluorescent supernanoparticles can also serve as an in vivo multi-photon and magnetic resonance dual-modal imaging probe.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Massachusetts Institute of Technology. Department of Chemistry
Massachusetts Institute of Technology. Department of Nuclear Science and Engineering
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Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1038/ncomms6093
