Protein potentials and domains : re-use and composability
Name
1015201724-MIT.pdf
Description
Full printable version
Size
4.73 MB
Format
Adobe PDF
Checksum (MD5)
c1239ceab62b1acebe355ac10a442771
Author(s)
Cunningham, Joseph M., M. Eng. Massachusetts Institute of Technology
Advisor(s)
Peter Sorger and Doug Lauffenberger.
Date Issued
2017
Publisher
Massachusetts Institute of Technology
Abstract
Protein-protein interactions are one of the cornerstones of biological processes throughout the cell. Unfortunately, lack of available data precludes many possible approaches to modeling these fundamental interactions at scale. This thesis focuses on a specific set of protein domains, known as peptide-binding domains (PBD), that play a particularly crucial role in mediating protein-protein interactions. Using these components as a basis, we develop a model for protein-protein interactions driven by PBDs. Our approach revises a previously proposed model, both expanding its applicability to a much larger set of PBDs and improving the performance of the model. We conclude with an application of our model that shows the flexibility of our approach.
Description
Thesis: M. Eng., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2017.
Cataloged from PDF version of thesis.
Includes bibliographical references (pages 29-31).
Subjects
Electrical Engineering and Computer Science.
MIT Department
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Terms of Use
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