Inhibitory Dendrite Dynamics as a General Feature of the Adult Cortical Microcircuit
Name
Chen-2011-Aug-Inhibitory dendrite dynamics.pdf
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1.28 MB
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Checksum (MD5)
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Author(s)
Chen, Jerry L.
Flanders, Genevieve H.
Lee, Wei-Chung Allen
Lin, Walter C.
Nedivi, Elly
Date Issued
August 2011
Journal
Journal of Neuroscience
Publisher
Society for Neuroscience
Citation
Chen, J. L. et al. “Inhibitory Dendrite Dynamics as a General Feature of the Adult Cortical Microcircuit.” Journal of Neuroscience 31.35 (2011): 12437-12443.
Version
Final published version
Abstract
The mammalian neocortex is functionally subdivided into architectonically distinct regions that process various types of information based on their source of afferent input. Yet, the modularity of neocortical organization in terms of cell type and intrinsic circuitry allows afferent drive to continuously reassign cortical map space. New aspects of cortical map plasticity include dynamic turnover of dendritic spines on pyramidal neurons and remodeling of interneuron dendritic arbors. While spine remodeling occurs in multiple cortical regions, it is not yet known whether interneuron dendrite remodeling is common across primary sensory and higher-level cortices. It is also unknown whether, like pyramidal dendrites, inhibitory dendrites respect functional domain boundaries. Given the importance of the inhibitory circuitry to adult cortical plasticity and the reorganization of cortical maps, we sought to address these questions by using two-photon microscopy to monitor interneuron dendritic arbors of thy1-GFP-S transgenic mice expressing GFP in neurons sparsely distributed across the superficial layers of the neocortex. We find that interneuron dendritic branch tip remodeling is a general feature of the adult cortical microcircuit, and that remodeling rates are similar across primary sensory regions of different modalities, but may differ in magnitude between primary sensory versus higher cortical areas. We also show that branch tip remodeling occurs in bursts and respects functional domain boundaries.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Picower Institute for Learning and Memory
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1523/jneurosci.0420-11.2011
