Variation of connectivity across exemplar sensory and associative thalamocortical loops in the mouse
Name
elife-62554-v2.pdf
Description
Published version
Size
6.25 MB
Format
Adobe PDF
Checksum (MD5)
56beead49a5e8f86d5136f4aa4348288
Author(s)
Mukherjee, Arghya
Bajwa, Navdeep
Lam, Norman H
Porrero, César
Clasca, Francisco
Halassa, Michael
Date Issued
October 2020
Journal
eLife
Publisher
eLife Sciences Publications, Ltd
Citation
Mukherjee, Arghya et al. "Variation of connectivity across exemplar sensory and associative thalamocortical loops in the mouse." eLife 9 (October 2020): e62554. © 2020 eLife Sciences Publications Ltd
Version
Final published version
Abstract
The thalamus engages in sensation, action, and cognition, but the structure underlying these functions is poorly understood. Thalamic innervation of associative cortex targets several interneuron types, modulating dynamics and influencing plasticity. Is this structure-function relationship distinct from that of sensory thalamocortical systems? Here, we systematically compared function and structure across a sensory and an associative thalamocortical loop in the mouse. Enhancing excitability of mediodorsal thalamus, an associative structure, resulted in prefrontal activity dominated by inhibition. Equivalent enhancement of medial geniculate excitability robustly drove auditory cortical excitation. Structurally, geniculate axons innervated excitatory cortical targets in a preferential manner and with larger synaptic terminals, providing a putative explanation for functional divergence. The two thalamic circuits also had distinct input patterns, with mediodorsal thalamus receiving innervation from a diverse set of cortical areas. Altogether, our findings contribute to the emerging view of functional diversity across thalamic microcircuits and its structural basis.
MIT Department
McGovern Institute for Brain Research at MIT
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Terms of Use
Creative Commons Attribution 4.0 International license
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DOI of Published Version
https://doi.org/10.7554/elife.62554
