Cycloid scanning for wide field optical coherence tomography endomicroscopy and angiography in vivo
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nihms951699.pdf
Description
Accepted version
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933.35 KB
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Checksum (MD5)
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Author(s)
Liang, Kaicheng
Wang, Zhao
Ahsen, Osman Oguz
Lee, Hsiang-Chieh
Potsaid, Benjamin M.
Jayaraman, Vijaysekhar
Cable, Alex
Mashimo, Hiroshi
Li, Xingde
Fujimoto, James G
Date Issued
January 2018
Journal
Optica
Publisher
OSA Publishing
Citation
Liang, Kaicheng et al. "Cycloid scanning for wide field optical coherence tomography endomicroscopy and angiography in vivo." Optica 5, 1 (January 2018): 36-43 © 2018 Optical Society of America
Version
Author's final manuscript
Abstract
Devices that perform wide field-of-view (FOV) precision optical scanning are important for endoscopic assessment and diagnosis of luminal organ disease such as in gastroenterology. Optical scanning for in vivo endoscopic imaging has traditionally relied on one or more proximal mechanical actuators, limiting scan accuracy and imaging speed. There is a need for rapid and precise two-dimensional (2D) microscanning technologies to enable the translation of benchtop scanning microscopies to in vivo endoscopic imaging. We demonstrate a new cycloid scanner in a tethered capsule for ultrahigh speed, side-viewing optical coherence tomography (OCT) endomicroscopy in vivo. The cycloid capsule incorporates two scanners: a piezoelectrically actuated resonant fiber scanner to perform a precision, small FOV, fast scan and a micromotor scanner to perform a wide FOV, slow scan. Together these scanners distally scan the beam circumferentially in a 2D cycloid pattern, generating an unwrapped1 mm× 38 mm strip FOV. Sequential strip volumes can be acquired with proximal pullback to image centimeter-long regions. Using ultrahigh speed 1.3 μm wavelength swept-source OCT at a 1.17 MHz axial scan rate, we imaged the human rectum at 3 volumes/s. Each OCT strip volume had 166 × 2322 axial scans with 8.5 μm axial and 30 μm transverse resolution. We further demonstrate OCT angiography at 0.5 volumes/s, producing volumetric images of vasculature. In addition to OCT applications, cycloid scanning promises to enable precision 2D optical scanning for other imaging modalities, including fluorescence confocal and nonlinear microscopy.
MIT Department
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Massachusetts Institute of Technology. Research Laboratory of Electronics
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DOI of Published Version
https://doi.org/10.1364/OPTICA.5.000036
