Defining the gut microbiota in individuals with periodontal diseases: an exploratory study
Name
Defining the gut microbiota in individuals with periodontal diseases an exploratory study.pdf
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2.56 MB
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Adobe PDF
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Author(s)
Lourenςo, Talita Gomes Baeta
Colombo, Ana Paula Vieira
Spencer, Sarah J.
Alm, Eric J
Date Issued
June 2018
Journal
Journal of Oral Microbiology
Publisher
Co-action Publishing
Citation
Lourenςo, Talita Gomes Baeta et al. “Defining the Gut Microbiota in Individuals with Periodontal Diseases: An Exploratory Study.” Journal of Oral Microbiology 10, 1 (January 2018): 1487741 © 2018 The Author(s)
Version
Final published version
Abstract
Background: This exploratory study aimed to characterize the gut microbiome of individuals with different periodontal conditions, and correlate it with periodontal inflammation and tissue destruction. Methods: Stool samples were obtained from individuals presenting periodontal health (PH = 7), gingivitis (G = 14) and chronic periodontitis (CP = 23). The intestinal microbiome composition was determined by Illumina MiSeq sequencing. Results: A lower alpha-diversity in the gut microbiome of individuals with CP was observed, although no significant difference among groups was found (p > 0.01). Firmicutes, Proteobacteria, Verrucomicrobia and Euryarchaeota were increased, whereas Bacteroidetes were decreased in abundance in patients with periodontitis compared to PH. Prevotella (genus), Comamonadaceae (family) and Lactobacillales (order) were detected in higher numbers in G, while Bacteroidales (order) was predominant in PH (p < 0.01). Significant correlations (rho = 0.337–0.468, p < 0.01) were found between OTUs representative of periodontal pathogens and attachment loss. Mogibacteriaceae, Ruminococcaceae and Prevotella were able to discriminate individuals with periodontal diseases from PH (overall accuracy = 84%). Oral taxa were detected in high numbers in all stool samples. Conclusions: Individuals with periodontal diseases present a less diverse gut microbiome consistent with other systemic inflammatory diseases. High numbers of oral taxa related to periodontal destruction and inflammation were detected in the gut microbiome of individuals regardless of periodontal status. Keywords: Gut microbiome; periodontal diseases; oral microorganisms; microbial metagenome; human microbiome
MIT Department
Massachusetts Institute of Technology. Computational and Systems Biology Program
Massachusetts Institute of Technology. Department of Biological Engineering
Abdul Latif Jameel Poverty Action Lab (Massachusetts Institute of Technology)
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Creative Commons Attribution 4.0 International License
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DOI of Published Version
https://doi.org/10.1080/20002297.2018.1487741
