Ubiquitination, Ubiquitin-like Modifiers, and Deubiquitination in Viral Infection
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Ploegh_Ubiquitination.pdf
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Author(s)
Isaacson, Marisa K.
Ploegh, Hidde
Date Issued
June 2009
Journal
Cell Host & Microbe
Publisher
Elsevier
Citation
Isaacson, Marisa K., and Hidde L. Ploegh. “Ubiquitination, Ubiquitin-like Modifiers, and Deubiquitination in Viral Infection.” Cell Host & Microbe 5, no. 6 (June 2009): 559-570. Copyright © 2009 Elsevier Inc.
Version
Final published version
Abstract
Ubiquitin is important for nearly every aspect of cellular physiology. All viruses rely extensively on host machinery for replication; therefore, it is not surprising that viruses connect to the ubiquitin pathway at many levels. Viral involvement with ubiquitin occurs either adventitiously because of the unavoidable usurpation of cellular processes, or for some specific purpose selected for by the virus to enhance viral replication. Here, we review current knowledge of how the ubiquitin pathway alters viral replication and how viruses influence the ubiquitin pathway to enhance their own replication.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Whitehead Institute for Biomedical Research
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1016/j.chom.2009.05.012
