Increases in Functional Connectivity between Prefrontal Cortex and Striatum during Category Learning
Name
Miller_Increases in.pdf
Size
1.72 MB
Format
Adobe PDF
Checksum (MD5)
3dc504411a68766c8a1466faa73b89b9
Author(s)
Antzoulatos, Evan G.
Miller, Earl K.
Antzoulatos, Evan G.
Miller, Earl K.
Date Issued
June 2014
Journal
Neuron
Publisher
Elsevier
Citation
Antzoulatos, Evan G., and Earl K. Miller. “Increases in Functional Connectivity Between Prefrontal Cortex and Striatum During Category Learning.” Neuron 83, no. 1 (July 2014): 216–225.
Version
Author's final manuscript
Abstract
Functional connectivity between the prefrontal cortex (PFC) and striatum (STR) is thought critical for cognition and has been linked to conditions like autism and schizophrenia. We recorded from multiple electrodes in PFC and STR while monkeys acquired new categories. Category learning was accompanied by an increase in beta band synchronization of LFPs between, but not within, the PFC and STR. After learning, different pairs of PFC-STR electrodes showed stronger synchrony for one or the other category, suggesting category-specific functional circuits. This category-specific synchrony was also seen between PFC spikes and STR LFPs, but not the reverse, reflecting the direct monosynaptic connections from the PFC to STR. However, causal connectivity analyses suggested that the polysynaptic connections from STR to the PFC exerted a stronger overall influence. This supports models positing that the basal ganglia “train” the PFC. Category learning may depend on the formation of functional circuits between the PFC and STR.
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Picower Institute for Learning and Memory
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/j.neuron.2014.05.005
