Depth-resolved microscopy of cortical hemodynamics with optical coherence tomography
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Fujimoto-Depth-resolved.pdf
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Author(s)
Srinivasan, Vivek J.
Sakadžic, Sava
Gorczynska, Iwona
Ruvinskaya, Svetlana
Wu, Weicheng
Fujimoto, James G.
Boas, David A.
Date Issued
October 2009
Journal
Optics Letters
Publisher
Optical Society of America
Citation
Srinivasan, Vivek J. et al. “Depth-resolved Microscopy of Cortical Hemodynamics with Optical Coherence Tomography.” Optics Letters 34.20 (2009): 3086.
Version
Author's final manuscript
Abstract
We describe depth-resolved microscopy of cortical hemodynamics with high-speed spectral/Fourier domain optical coherence tomography (OCT). Stimulus-evoked changes in blood vessel diameter, flow, and total hemoglobin were measured in the rat somatosensory cortex. The results show OCT measurements of hemodynamic changes during functional activation and represent an important step toward understanding functional hyperemia at the microscopic level.
MIT Department
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike 3.0
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DOI of Published Version
https://doi.org/10.1364/OL.34.003086
