Evaluation of an intramedullary bone stabilization system using a light-curable monomer in sheep
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Edelman_Evaluation of.pdf
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Author(s)
Zani, Brett G.
Baird, Rose
Stanley, James R. L.
Markham, Peter M.
Wilke, Markus
Zeiter, Stephan
Beck, Aswin
Nehrbass, Dirk
Kopia, Gregory A.
Rabiner, Robert
Date Issued
February 2016
Journal
Journal of Biomedical Materials Research Part B: Applied Biomaterials
Publisher
Wiley Blackwell
Citation
Zani, Brett G., Rose Baird, James R. L. Stanley, Peter M. Markham, Markus Wilke, Stephan Zeiter, Aswin Beck, et al. “Evaluation of an Intramedullary Bone Stabilization System Using a Light-Curable Monomer in Sheep.” J. Biomed. Mater. Res. 104, no. 2 (March 12, 2015): 291–299.
Version
Author's final manuscript
Abstract
Percutaneous intramedullary fixation may provide an ideal method for stabilization of bone fractures, while avoiding the need for large tissue dissections. Tibiae in 18 sheep were treated with an intramedullary photodynamic bone stabilization system (PBSS) that comprised a polyethylene terephthalate (Dacron) balloon filled with a monomer, cured with visible light in situ, and then harvested at 30, 90, or 180 days. In additional 40 sheep, a midshaft tibial osteotomy was performed and stabilized with external fixators or external fixators combined with the PBSS and evaluated at 8, 12, and 26 weeks. Healing and biocompatibility were evaluated by radiographic analysis, micro-computed tomography, and histopathology. In nonfractured sheep tibiae, PBSS implants conformably filled the medullary canal, while active cortical bone remodeling and apposition of new periosteal and/or endosteal bone was observed with no significant macroscopic or microscopic observations. Fractured sheep tibiae exhibited increased bone formation inside the osteotomy gap, with no significant difference when fixation was augmented by PBSS implants. Periosteal callus size gradually decreased over time and was similar in both treatment groups. No inhibition of endosteal bone remodeling or vascularization was observed with PBSS implants. Intramedullary application of a light-curable PBSS is a biocompatible, feasible method for fracture fixation
MIT Department
Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Harvard University--MIT Division of Health Sciences and Technology
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DOI of Published Version
https://doi.org/10.1002/jbm.b.33380
