Overcoming the challenges in administering biopharmaceuticals: formulation and delivery strategies
Name
nihms689451.pdf
Description
Accepted version
Size
2.53 MB
Format
Adobe PDF
Checksum (MD5)
ede354ae84e277ceecbb8756c9adfafe
Author(s)
Mitragotri, Samir
Burke, Paul A
Langer, Robert
Date Issued
2014
Journal
Nature Reviews Drug Discovery
Publisher
Springer Science and Business Media LLC
Citation
Mitragotri, S., P. A. Burke, and R. Langer. "Overcoming the Challenges in Administering Biopharmaceuticals: Formulation and Delivery Strategies." Nat Rev Drug Discov 13 9 (2014): 655-72.
Version
Author's final manuscript
Abstract
© 2014 Macmillan Publishers Limited. All rights reserved. The formulation and delivery of biopharmaceutical drugs, such as monoclonal antibodies and recombinant proteins, poses substantial challenges owing to their large size and susceptibility to degradation. In this Review we highlight recent advances in formulation and delivery strategies - such as the use of microsphere-based controlled-release technologies, protein modification methods that make use of polyethylene glycol and other polymers, and genetic manipulation of biopharmaceutical drugs - and discuss their advantages and limitations. We also highlight current and emerging delivery routes that provide an alternative to injection, including transdermal, oral and pulmonary delivery routes. In addition, the potential of targeted and intracellular protein delivery is discussed.
MIT Department
Massachusetts Institute of Technology. Department of Chemical Engineering
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1038/NRD4363
