Reversible, Long-Range Radical Transfer in E. coli Class Ia Ribonucleotide Reductase
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Stubbe_Reversible, long-range.pdf
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Author(s)
Minnihan, Ellen Catherine
Stubbe, JoAnne
Nocera, Daniel G.
Date Issued
June 2013
Journal
Accounts of Chemical Research
Publisher
American Chemical Society (ACS)
Citation
Minnihan, Ellen C., Daniel G. Nocera, and JoAnne Stubbe. “Reversible, Long-Range Radical Transfer in E. Coli Class Ia Ribonucleotide Reductase.” Acc. Chem. Res. 46, no. 11 (November 19, 2013): 2524–2535.
Version
Author's final manuscript
Abstract
Ribonucleotide reductases (RNRs) catalyze the conversion of nucleotides (NDPs or NTPs where N = C, U, G, or A) to 2′-deoxynucleotides (dNDPs or dNTPs)[superscript 1] and are responsible for controlling the relative ratios and absolute concentrations of cellular dNTP pools. For this reason, RNRs play a major role in ensuring the fidelity of DNA replication and repair. RNRs are found in all organisms and are classified based on the metallocofactor used to initiate catalysis,[superscript 1] with the class Ia RNRs requiring a diferric-tyrosyl radical (Y•) cofactor.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Massachusetts Institute of Technology. Department of Chemistry
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1021/ar4000407
