A microcomposite hydrogel for repeated on-demand ultrasound-triggered drug delivery
Name
nihms-193890.pdf
Description
Accepted version
Size
1.45 MB
Format
Adobe PDF
Checksum (MD5)
41004b30ad6b5bddfd2dd902f3d7c1b6
Author(s)
Epstein-Barash, Hila
Orbey, Gizem
Polat, Baris E.
Ewoldt, Randy H.
Feshitan, Jameel
Langer, Robert S
Borden, Mark A.
Kohane, Daniel S
Date Issued
March 2010
Journal
Biomaterials
Publisher
Elsevier BV
Citation
Epstein-Barash, Hila et al., "A microcomposite hydrogel for repeated on-demand ultrasound-triggered drug delivery." Biomaterials 31,19 (July 2010): p. 5208-17 doi. 10.1016/j.biomaterials.2010.03.008 ©2010 Authors
Version
Author's final manuscript
Abstract
Here we develop an injectable composite system based for repeated ultrasound-triggered on-demand drug delivery. An in situ-cross-linking hydrogel maintains model drug (dye)-containing liposomes in close proximity to gas-filled microbubbles that serve to enhance release events induced by ultrasound application. Dye release is tunable by varying the proportions of the liposomal and microbubble components, as well as the duration and intensity of the ultrasound pulses in vitro. Dye is minimal at baseline. The composite shows minimal cytotoxicity in vitro, and benign tissue reaction after subcutaneous injection in rats. Ultrasound application also triggers drug release for two weeks after injection in vivo. ©2010 Elsevier Ltd.
MIT Department
Harvard University--MIT Division of Health Sciences and Technology
Massachusetts Institute of Technology. Department of Mechanical Engineering
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
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DOI of Published Version
https://doi.org/10.1016/j.biomaterials.2010.03.008
