The Nuclear Pore Complex as a Flexible and Dynamic Gate
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nihms755335.pdf
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1.19 MB
Format
Adobe PDF
Checksum (MD5)
2af5addc81e9df5078571e7d178c5c0d
Author(s)
Knockenhauer, Kevin Edward
Schwartz, Thomas
Date Issued
March 2016
Journal
Cell
Publisher
Elsevier
Citation
Knockenhauer, Kevin E., and Thomas U. Schwartz. “The Nuclear Pore Complex as a Flexible and Dynamic Gate.” Cell 164, 6 (March 2016): 1162–1171 © 2016 Elsevier Inc
Version
Author's final manuscript
Abstract
Nuclear pore complexes (NPCs) perforate the nuclear envelope and serve as the primary transport gates for molecular exchange between nucleus and cytoplasm. Stripping the megadalton complex down to its most essential organizational elements, one can divide the NPC into scaffold components and the disordered elements attached to them that generate a selective barrier between compartments. These structural elements exhibit flexibility, which may hold a clue in understanding NPC assembly and function. Here we review the current status of NPC research with a focus on the functional implications of its structural and compositional heterogeneity.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
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DOI of Published Version
https://doi.org/10.1016/J.CELL.2016.01.034
