Simulated Surface-Induced Thrombin Generation in a Flow Field
Name
Jordan-2011-Simulated Surface-In.pdf
Size
921.38 KB
Format
Adobe PDF
Checksum (MD5)
4ab2f9ea0f78014caf396437b3499ead
Author(s)
Jordan, S.W.
Chaikof, Elliot L.
Date Issued
July 2011
Journal
Biophysical Journal
Publisher
Elsevier
Citation
Jordan, S.W., and E.L. Chaikof. “Simulated Surface-Induced Thrombin Generation in a Flow Field.” Biophysical Journal 101, no. 2 (July 2011): 276–286. © 2011 Biophysical Society
Version
Final published version
Abstract
A computational model of blood coagulation is presented with particular emphasis on the regulatory effects of blood flow, spatial distribution of tissue factor (TF), and the importance of the thrombomodulin-activated protein C inhibitory pathway. We define an effective prothrombotic zone that extends well beyond the dimensions of injury. The size of this zone is dependent on the concentrations of all reactive species, the dimensions of TF expression, the densities of surface molecules, and the characteristics of the flow field. In the case of tandem sites of TF, the relationship between the magnitude of the effective prothrombotic zone and the interval distance between TF sites dictate the net response of the system. Multiple TF sites, which individually failed to activate the coagulation pathway, are shown to interact in an additive manner to yield a prothrombotic system. Furthermore, activation of the thrombomodulin-activated protein C pathway in the regions between sites of TF downregulate the thrombin response at subsequent TF sites. The implications of prothrombotic effects, which extend downstream beyond the discrete site of injury to interact with subsequent lesions are critical given the systemic nature of atherosclerotic disease.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/j.bpj.2011.05.056
