ChemoRad nanoparticles: a novel multifunctional nanoparticle platform for targeted delivery of concurrent chemoradiation
Name
nihms-207239.pdf
Description
Accepted version
Size
846.99 KB
Format
Adobe PDF
Checksum (MD5)
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Author(s)
Wang, Andrew Z
Yuet, Kai
Zhang, Liangfang
Gu, Frank X
Huynh-Le, Minh
Radovic-Moreno, Aleksandar F
Kantoff, Philip W
Bander, Neil H
Langer, Robert
Farokhzad, Omid C
Date Issued
2010
Journal
Nanomedicine: Nanotechnology, Biology, and Medicine
Publisher
Future Medicine Ltd
Citation
Wang, A. Z., et al. "Chemorad Nanopartides: A Novel Multifunctional Nanoparticle Platform for Targeted Delivery of Concurrent Chemoradiation." Nanomedicine 5 3 (2010): 361-68.
Version
Author's final manuscript
Abstract
Aim: The development of chemoradiation - the concurrent administration of chemotherapy and radiotherapy - has led to significant improvements in local tumor control and survival. However, it is limited by its high toxicity. In this study, we report the development of a novel NP (nanoparticle) therapeutic, ChemoRad NP, which can deliver biologically targeted chemoradiation. Method: A biodegradable and biocompatible lipid-polymer hybrid NP that is capable of delivering both chemotherapy and radiotherapy was formulated. Results: Using docetaxel, indium111 and yttrium90 as model drugs, we demonstrated that the ChemoRad NP can encapsulate chemotherapeutics (up to 9% of NP weight) and radiotherapeutics (100 mCi of radioisotope per gram of NP) efficiently and deliver both effectively. Using prostate cancer as a disease model, we demonstrated the targeted delivery of ChemoRad NPs and the higher therapeutic efficacy of ChemoRad NPs. Conclusion: We believe that the ChemoRad NP represents a new class of therapeutics that holds great potential to improve cancer treatment. © 2010 Future Medicine Ltd.
MIT Department
Massachusetts Institute of Technology. Department of Chemical Engineering
Harvard University--MIT Division of Health Sciences and Technology
Massachusetts Institute of Technology. Department of Biological Engineering
Koch Institute for Integrative Cancer Research at MIT
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Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.2217/nnm.10.6
