Manufacturing of Lab-On-a-Chip devices : variation analysis of liquid delivery using blister packs
Name
712601407-MIT.pdf
Description
Full printable version
Size
10.69 MB
Format
Adobe PDF
Checksum (MD5)
0466c225c61d330029df28d05951840f
Author(s)
Selvakumar, Sivesh
Advisor(s)
Brian Anthony.
Alternative Title
Manufacturing of LOC devices : variation analysis of liquid delivery using blister packs
Date Issued
2010
Publisher
Massachusetts Institute of Technology
Abstract
Components for on-chip storage and delivery of liquid reagent are necessary for many commercial applications of lab-on-a-chip technology. One such system uses a 'blister pack' that is pushed by an actuator. Over the course of product development, Daktari Diagnostics had completed nominal design of a blister pack for their flow rate requirements. This work involved performing a thorough variation analysis of the blister pack to determine the critical sources of variation. For this purpose, the tool of variation simulation modeling (VSM) was used. A numerical model of the blister performance was developed and Monte Carlo simulations were conducted. The results showed that this fluid delivery technique is robust and the number of out-of-specification parts was less than 2%. The critical blister pack parameters that must be controlled were also determined and these can be used to improve process capability.
Description
Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2010.
Cataloged from PDF version of thesis.
Includes bibliographical references (p. [81]-82).
Subjects
Mechanical Engineering.
MIT Department
Massachusetts Institute of Technology. Department of Mechanical Engineering
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