7.346 Virus-host Interactions in Infectious Diseases, Spring 2013
Name
7.346-spring-2013.zip
Description
This package contains the same content as the online version of the course, except for the audio/video materials.
Size
7.84 MB
Format
ZIP
Checksum (MD5)
2ebece697a53c2a20f8a09f48068a592
Author(s)
Sanyal, Sumana
Ashour, Joseph
Date Issued
June 2013
Abstract
Co-evolution and adaptation between viruses and humans are often portrayed as a zero-sum biological arms race. Viruses enter host cells equipped with an array of mechanisms to evade the host defense responses and replicate. The rapid rate of mutation of viruses permits evolution of various methodologies for infection, which in turn drive development of non-specific but highly effective host mechanisms to restrict infection. This class will discuss the varied solutions each side has developed as a means for survival. We will use examples drawn from human disease-causing pathogens that contribute seriously to the global health burden, including HIV, influenza and dengue virus. Primary research papers will be discussed to help students learn to pose scientific questions and design and conduct experiments to answer the questions and critically interpret data. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanced Undergraduate Seminars are postdoctoral scientists with a strong interest in teaching.
Subjects
virus
host
infection
protein-protein interactions
host mimicry
intra-cellular trafficking
host-cell machinery
signaling pathways
antiviral proteins
HIV
influenza
dengue virus
biotechnology
vaccine development
host sensors
IFN production
Secreted IFN
filoviruses
hCMV
IFITM proteins
MIT Department
Massachusetts Institute of Technology. Department of Biology
Terms of Use
Attribution-NonCommercial-NoDerivs 3.0 United States
Persistent DSpace Link
