YY1 Regulates Melanocyte Development and Function by Cooperating with MITF
Name
Li-2012-YY1 Regulates Melano.pdf
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3.04 MB
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Author(s)
Li, Juying
Song, Jun S.
Bell, Robert J. A.
Tran, Thanh-Nga T.
Haq, Rizwan
Liu, Huifei
Love, Kevin T.
Langer, Robert
Anderson, Daniel G.
Larue, Lionel
Date Issued
May 2012
Journal
PLoS Genetics
Publisher
Public Library of Science
Citation
Li, Juying et al. “YY1 Regulates Melanocyte Development and Function by Cooperating with MITF.” Ed. Marcus Bosenberg. PLoS Genetics 8.5 (2012): e1002688.
Version
Final published version
Abstract
Studies of coat color mutants have greatly contributed to the discovery of genes that regulate melanocyte development and function. Here, we generated Yy1 conditional knockout mice in the melanocyte-lineage and observed profound melanocyte deficiency and premature gray hair, similar to the loss of melanocytes in human piebaldism and Waardenburg syndrome. Although YY1 is a ubiquitous transcription factor, YY1 interacts with M-MITF, the Waardenburg Syndrome IIA gene and a master transcriptional regulator of melanocytes. YY1 cooperates with M-MITF in regulating the expression of piebaldism gene KIT and multiple additional pigmentation genes. Moreover, ChIP–seq identified genome-wide YY1 targets in the melanocyte lineage. These studies mechanistically link genes implicated in human conditions of melanocyte deficiency and reveal how a ubiquitous factor (YY1) gains lineage-specific functions by co-regulating gene expression with a lineage-restricted factor (M-MITF)—a general mechanism which may confer tissue-specific gene expression in multiple lineages.
MIT Department
Harvard University--MIT Division of Health Sciences and Technology
Massachusetts Institute of Technology. Department of Chemical Engineering
Koch Institute for Integrative Cancer Research at MIT
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DOI of Published Version
https://doi.org/10.1371/journal.pgen.1002688
