Chirality dependent corona phase molecular recognition of DNA-wrapped carbon nanotubes
Name
Salem_etal_Carbon_2016.pdf
Size
561.9 KB
Format
Adobe PDF
Checksum (MD5)
d1ccb0e0ee9dde5afc9f36b67356f386
Author(s)
Kruss, Sebastian
Salem, Daniel Parker
Landry, Markita P
Bisker Raviv, Gili Hana
Ahn, Jiyoung
Strano, Michael S.
Date Issued
August 2015
Journal
Carbon
Publisher
Elsevier
Citation
Salem, Daniel P. et al. “Chirality Dependent Corona Phase Molecular Recognition of DNA-Wrapped Carbon Nanotubes.” Carbon 97 (February 2016): 147–153 © 2015 Elsevier Ltd
Version
Author's final manuscript
Abstract
Corona phase molecular recognition (CoPhMoRe) is a phenomenon whereby a polymer or surfactant corona phase wrapped around a nanoparticle selectively recognizes a particular molecule. The method can potentially generate non-biological, synthetic molecular recognition sites, analogous to antibodies, for a broad range of biomedical applications, including new types of sensors, laboratory and clinical assays, as well as inhibitors and targeted therapeutics. In this work, we utilize near infrared fluorescent single-walled carbon nanotubes (SWNTs) wrapped with specific single stranded DNA sequences to explore the (n,m) chirality dependence of CoPhMoRe. Specific DNA oligonucleotide sequences are known to recognize and interact uniquely with certain (n,m) SWNTs enabling their enrichment in ion exchange chromatography. We explore the CoPhMoRe effect using corona phases constructed from a library of 24 such sequences, screening against a biomolecule panel that includes common neurotransmitters, amino acids, saccharides and riboflavin. Example sequences include (ATT)₄, (TAT)₄ and (ATTT)₃ which recognize (7,5), (6,5) and (8,4) SWNTs, respectively. We find that these recognition sequences indeed form CoPhMoRe phases that are distinct among SWNT chiralities, and appear to pack more densely as to exclude analyte adsorption on the chirality they recognize. These results have encouraging implications for the controlled design of CoPhMoRe phases for biomedical applications.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/j.carbon.2015.08.075
