Control of the Embryonic Stem Cell State
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Young_Control of.pdf
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1.17 MB
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Author(s)
Young, Richard A.
Young, Richard A.
Date Issued
March 2011
Journal
Cell
Publisher
Elsevier B.V.
Citation
Young, Richard A. “Control of the Embryonic Stem Cell State.” Cell 144, no. 6 (March 2011): 940–954.© 2011 Elsevier Inc.
Version
Final published version
Abstract
Embryonic stem cells and induced pluripotent stem cells hold great promise for regenerative medicine. These cells can be propagated in culture in an undifferentiated state but can be induced to differentiate into specialized cell types. Moreover, these cells provide a powerful model system for studies of cellular identity and early mammalian development. Recent studies have provided insights into the transcriptional control of embryonic stem cell state, including the regulatory circuitry underlying pluripotency. These studies have, as a consequence, uncovered fundamental mechanisms that control mammalian gene expression, connect gene expression to chromosome structure, and contribute to human disease.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Whitehead Institute for Biomedical Research
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1016/j.cell.2011.01.032
