Macroporous nanowire nanoelectronic scaffolds for synthetic tissues
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Langer_Macroporous_nanowire.pdf
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2.52 MB
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Checksum (MD5)
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Author(s)
Tian, Bozhi
Dvir, Tal
Jin, Lihua
Tsui, Jonathan H.
Qing, Quan
Suo, Zhigang
Kohane, Daniel S.
Lieber, Charles M.
Liu, Jia, 1972-
Langer, Robert S
Date Issued
November 2012
Journal
Nature Materials
Publisher
Nature Publishing Group
Citation
Tian, Bozhi, Jia Liu, Tal Dvir, et al. 2012 Macroporous Nanowire Nanoelectronic Scaffolds for Synthetic Tissues. Nature Materials 11(11): 986–994.
Version
Author's final manuscript
Abstract
The development of three-dimensional (3D) synthetic biomaterials as structural and bioactive scaffolds is central to fields ranging from cellular biophysics to regenerative medicine. As of yet, these scaffolds cannot electrically probe the physicochemical and biological microenvironments throughout their 3D and macroporous interior, although this capability could have a marked impact in both electronics and biomaterials. Here, we address this challenge using macroporous, flexible and free-standing nanowire nanoelectronic scaffolds (nanoES), and their hybrids with synthetic or natural biomaterials. 3D macroporous nanoES mimic the structure of natural tissue scaffolds, and they were formed by self-organization of coplanar reticular networks with built-in strain and by manipulation of 2D mesh matrices. NanoES exhibited robust electronic properties and have been used alone or combined with other biomaterials as biocompatible extracellular scaffolds for 3D culture of neurons, cardiomyocytes and smooth muscle cells. Furthermore, we show the integrated sensory capability of the nanoES by real-time monitoring of the local electrical activity within 3D nanoES/cardiomyocyte constructs, the response of 3D-nanoES-based neural and cardiac tissue models to drugs, and distinct pH changes inside and outside tubular vascular smooth muscle constructs.
Description
available in PMC 2013 April 11.
MIT Department
Massachusetts Institute of Technology. Department of Chemical Engineering
Koch Institute for Integrative Cancer Research at MIT
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1038/nmat3404
