A Phase Separation Model for Transcriptional Control
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Author(s)
Hnisz, Denes
Young, Richard A.
Chakraborty, Arup K.
Sharp, Phillip A.
Shrinivas, Krishna,Ph. D.Massachusetts Institute of Technology.
Date Issued
March 2017
Journal
Cell
Publisher
Elsevier
Citation
Hnisz, Denes, et al. “A Phase Separation Model for Transcriptional Control.” Cell 169, 1 (March 2017): 13–23 © 2017 Elsevier Inc
Version
Author's final manuscript
Abstract
Phase-separated multi-molecular assemblies provide a general regulatory mechanism to compartmentalize biochemical reactions within cells. We propose that a phase separation model explains established and recently described features of transcriptional control. These features include the formation of super-enhancers, the sensitivity of super-enhancers to perturbation, the transcriptional bursting patterns of enhancers, and the ability of an enhancer to produce simultaneous activation at multiple genes. This model provides a conceptual framework to further explore principles of gene control in mammals. Keywords: super-enhancer; enhancer; phase separation; transcription; nuclear body; gene control; bursting; transcriptional burst; co-operativity
MIT Department
Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Biology
Massachusetts Institute of Technology. Department of Chemical Engineering
Massachusetts Institute of Technology. Department of Chemistry
Massachusetts Institute of Technology. Department of Physics
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
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DOI of Published Version
https://doi.org/10.1016/J.CELL.2017.02.007
