Bacterial Responses to Iron Withholding by Calprotectin
Name
nihms-1748686.pdf
Description
Accepted version
Size
797.92 KB
Format
Adobe PDF
Checksum (MD5)
c541b41e443c8460611709ebbda113ab
Author(s)
Obisesan, Adunoluwa O
Zygiel, Emily M
Nolan, Elizabeth M
Date Issued
2021
Journal
Biochemistry
Publisher
American Chemical Society (ACS)
Citation
Obisesan, Adunoluwa O, Zygiel, Emily M and Nolan, Elizabeth M. 2021. "Bacterial Responses to Iron Withholding by Calprotectin." Biochemistry, 60 (45).
Version
Author's final manuscript
Abstract
Iron (Fe) plays important roles in both essential cellular processes and virulence pathways for many bacteria. Consequently, Fe withholding by the human innate immune system is an effective form of defense against bacterial infection. In this Perspective, we review recent studies that have established a foundation for our understanding of the impact of the metal-sequestering host defense protein calprotectin (CP) on bacterial Fe homeostasis. We also discuss two recently uncovered strategies for bacterial adaptation to Fe withholding by CP. Together, these studies provide insight into how Fe sequestration by CP affects bacterial pathogens that include Pseudomonas aeruginosa, Acinetobacter baumannii, and Staphylococcus aureus. Overall, recent studies suggest that Fe withholding by CP may have implications for bacterial survival and virulence in the host, and further explorations that directly address this possibility present an important area for discovery.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1021/ACS.BIOCHEM.1C00572
