Ventral CA1 neurons store social memory
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Okuyama et al, Final.pdf
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Author(s)
Itohara, Shigeyoshi
Okuyama, Teruhiro
Kitamura, Takashi
Roy, Dheeraj
Tonegawa, Susumu
Date Issued
September 2016
Journal
Science
Publisher
American Association for the Advancement of Science (AAAS)
Citation
Okuyama, T., T. Kitamura, D. S. Roy, S. Itohara, and S. Tonegawa. “Ventral CA1 Neurons Store Social Memory.” Science 353, no. 6307 (September 29, 2016): 1536-1541.
Version
Author's final manuscript
Abstract
The medial temporal lobe, including the hippocampus, has been implicated in social memory. However, it remains unknown which parts of these brain regions and their circuits hold social memory. Here, we show that ventral hippocampal CA1 (vCA1) neurons of a mouse and their projections to nucleus accumbens (NAc) shell play a necessary and sufficient role in social memory. Both the proportion of activated vCA1 cells and the strength and stability of the responding cells are greater in response to a familiar mouse than to a previously unencountered mouse. Optogenetic reactivation of vCA1 neurons that respond to the familiar mouse enabled memory retrieval and the association of these neurons with unconditioned stimuli. Thus, vCA1 neurons and their NAc shell projections are a component of the storage site of social memory.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Picower Institute for Learning and Memory
RIKEN-MIT Center for Neural Circuit Genetics
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1126/science.aaf7003
