Finite Element Framework for Mechanics and Dynamics of Supramolecular Protein Assemblies
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Bathe_Finite Element.pdf
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Author(s)
Kim, Do-Nyun
Sharifi Sedeh, Reza
Nguyen, Cong Tri
Bathe, Mark
Date Issued
February 2010
Journal
Proceedings of the ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology (NEMB2010)
Publisher
American Society of Mechanical Engineers
Citation
Kim, Do-Nyun et al. "Finite Element Framework for Mechanics and Dynamics of Supramolecular Protein Assemblies." in Proceedings of ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology
NEMB2010, February 7-10, 2010 Houston, TX, USA. © 2010 ASME.
Version
Final published version
Abstract
Introducation: The conformational dynamics and mechanical
properties of supramolecular protein assemblies play a central
role in a broad array of cellular functions ranging from
migration and division to transcription and translation. The
finite element method (FEM) provides a natural framework for
the computation of protein normal modes and mechanical
response based either on atomic coordinates or electron density
maps [1]. Here, we present development of the finite element
framework for the computation of actin filament mechanics and
solvent damping effects. A new normal modes data bank for
structures in the electron microscopy data bank (EMDB [2]) is
also presented.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Mechanical Engineering
Massachusetts Institute of Technology. Laboratory for Computational Cell Biology & Biophysics
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