Platforms for Biological Control
Name
gretton-dgretton-MS-MAS-2022-thesis.pdf
Description
Thesis PDF
Size
23.82 MB
Format
Adobe PDF
Checksum (MD5)
af0c9a50ccf5436bc8de9603284b7ea1
Author(s)
Gretton, Dana
Advisor(s)
Esvelt, Kevin M.
Date Issued
September 2022
Publisher
Massachusetts Institute of Technology
Abstract
Innovation at the level of platforms provides the greatest leverage for shaping science and technology. Here, two key weaknesses in platforms for biology are addressed: the lack of accessible, extensible open-source software for the exploding field of robotic bioautomation, and the lack of a standardized, consistent screening platform for the manufacture of dangerous DNA. Pyhamilton and SecureDNA are introduced. Pyhamilton is the first open-source Python package for controlling Hamilton liquid-handling robots for biology. SecureDNA is the only DNA screening concept to prioritize anti-proliferation of pathogen genomes, and the first to employ modern cryptography to secure a global screening system that can keep up with anticipated exponential growth of the DNA synthesis market. For each platform developed, a software implementation is provided and exercised in a range of applications, and hardware demonstrators have been produced.
MIT Department
Program in Media Arts and Sciences (Massachusetts Institute of Technology)
Terms of Use
In Copyright - Educational Use Permitted
Copyright MIT
Persistent DSpace Link
