Formation of organic molecular nanocrystals under rigid confinement with analysis by solid state NMR
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Griffin_Formation of organic.pdf
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Author(s)
Ong, Ta-Chung
Michaelis, Vladimir K.
Heng, Scott N.
Huang, J.
Griffin, Robert Guy
Myerson, Allan S.
Yang, X.
Date Issued
August 2014
Journal
CrystEngComm
Publisher
Royal Society of Chemistry
Citation
Yang, X. et al. “Formation of Organic Molecular Nanocrystals under Rigid Confinement with Analysis by Solid State NMR.” CrystEngComm 16.39 (2014): 9345–9352.
Version
Author's final manuscript
Abstract
Crystallization in rigid confinement is a promising method to obtain organic molecular nanocrystals. However, the crystallization behavior and the related characterization methods are not well studied. Here we present a systematic study of the nucleation of organic molecular nanocrystals in rigid pores. Four different compounds were studied, ibuprofen, fenofibrate, griseofulvin, and indomethacin, which range from simple to complex molecules. Solid-state Nuclear Magnetic Resonance (NMR) was employed to analyse the structure of these compounds inside pores which are difficult to characterize by other analytical methods. We successfully demonstrated the production of nano-crystalline ibuprofen, fenofibrate and griseofulvin in porous silica particles with ~ 40 nm pores. These nanocrystals showed significant enhancement in dissolution rates. These results help advance the fundamental understanding of nucleation under rigid confinement and may lead to potential applications in developing new formulations in the pharmaceutical industry.
MIT Department
Massachusetts Institute of Technology. Department of Chemical Engineering
Massachusetts Institute of Technology. Department of Chemistry
Francis Bitter Magnet Laboratory (Massachusetts Institute of Technology)
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DOI of Published Version
https://doi.org/10.1039/c4ce01087f
