Compact Zwitterion-Coated Iron Oxide Nanoparticles for Biological Applications
Name
Bawendi_Compact Zwitterion-coated.pdf
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1.63 MB
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Checksum (MD5)
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Author(s)
Wei, He
Insin, Numpon
Lee, Jungmin
Han, Hee-Sun
Liu, Wenhao
Bawendi, Moungi G.
Cordero Hernandez, Jose M.
Date Issued
December 2011
Journal
Nano Letters
Publisher
American Institute of Physics (AIP)
Citation
Wei, He, Numpon Insin, Jungmin Lee, Hee-Sun Han, Jose M. Cordero, Wenhao Liu, and Moungi G. Bawendi. “Compact Zwitterion-Coated Iron Oxide Nanoparticles for Biological Applications.” Nano Letters 12, no. 1 (January 11, 2012): 22-25.
Version
Author's final manuscript
Abstract
The potential of superparamagnetic iron oxide nanoparticles (SPIONs) in various biomedical applications, including magnetic resonance imaging (MRI), sensing, and drug delivery, requires that their surface be derivatized to be hydrophilic and biocompatible. We report here the design and synthesis of a compact and water-soluble zwitterionic dopamine sulfonate (ZDS) ligand with strong binding affinity to SPIONs. After ligand exchange, the ZDS-coated SPIONs exhibit small hydrodynamic diameters, and stability with respect to time, pH, and salinity. Furthermore, small ZDS coated SPIONs were found to have a reduced nonspecific affinity (compared to negatively charged SPIONs) toward serum proteins; streptavidin/dye functionalized SPIONs were bioactive and thus specifically targeted biotin receptors.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1021/nl202721q
