Evaluation of accuracy dependence of Raman spectroscopic models on the ratio of calibration and validation points for non-invasive glucose sensing
Name
nihms-1501239.pdf
Description
Accepted version
Size
833.9 KB
Format
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Checksum (MD5)
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Author(s)
Singh, Surya P
Mukherjee, Soumavo
Galindo, Luis H
So, Peter TC
Dasari, Ramachandra Rao
Khan, Uzma Zubair
Kannan, Raghuraman
Upendran, Anandhi
Kang, Jeon Woong
Date Issued
2018
Journal
Analytical and Bioanalytical Chemistry
Publisher
Springer Nature
Version
Author's final manuscript
Abstract
© 2018, Springer-Verlag GmbH Germany, part of Springer Nature. Optical monitoring of blood glucose levels for non-invasive diagnosis is a growing area of research. Recent efforts in this direction have been inclined towards reducing the requirement of calibration framework. Here, we are presenting a systematic investigation on the influence of variation in the ratio of calibration and validation points on the prospective predictive accuracy of spectral models. A fiber-optic probe coupled Raman system has been employed for transcutaneous measurements. Limit of agreement analysis between serum and partial least square regression predicted spectroscopic glucose values has been performed for accurate comparison. Findings are suggestive of strong predictive accuracy of spectroscopic models without requiring substantive calibration measurements. [Figure not available: see fulltext.].
MIT Department
Massachusetts Institute of Technology. Laser Biomedical Research Center
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Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1007/S00216-018-1244-Y
