Oocyte differentiation is genetically dissociable from the meiotic program in mice
Name
844345907-MIT.pdf
Description
Full printable version
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8.83 MB
Format
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Checksum (MD5)
4f1dd9a4c393f954d767d99ca26ce7b8
Author(s)
Dokshin, Gregoriy A. (Gregoriy Aleksandrovich)
Advisor(s)
David C. Page.
Date Issued
2013
Publisher
Massachusetts Institute of Technology
Abstract
Oogenesis is a developmental program by which a gametogenesis-competent germ cell becomes a fertilization-competent egg. During oogenesis, growth and differentiation of oocytes are closely coordinated with initiation and progression through meiosis. In mammals, the timing of meiotic initiation is sexually dimorphic, with only ovarian and not testicular germ cells initiating meiosis during fetal development. Consequentially, fetal meiotic initiation is thought to be prerequisite to subsequent growth and differentiation of the ovarian germ cell into a fully grown oocyte. Here I present evidence that meiotic initiation and prophase I are genetically separable from oocyte growth and differentiation, thereby, demonstrating that oogenesis consists of two independent processes under separate regulation. This represents a novel view of the oogenesis program and revises the current model of germ cell commitment to oogenesis in mice. The proposed revised model accounts for independent commitment of a germ cell to meiosis and differentiation. This model may provide insights into previously unexplained cases of female infertility and has practical implications for in vitro oogenesis strategies.
Description
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2013.
Cataloged from PDF version of thesis. Page 100 blank.
Includes bibliographical references.
Subjects
Biology.
MIT Department
Massachusetts Institute of Technology. Department of Biology
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