The Human Cell Atlas
Name
elife-27041-v2.pdf
Size
16.27 MB
Format
Adobe PDF
Checksum (MD5)
39d5755b601057fda99560f711262028
Author(s)
Teichmann, Sarah A
Amit, Ido
Benoist, Christophe
Birney, Ewan
Bodenmiller, Bernd
Campbell, Peter
Carninci, Piero
Clatworthy, Menna
Clevers, Hans
Deplancke, Bart
Date Issued
December 2017
Journal
eLife
Publisher
eLife Sciences Publications, Ltd
Citation
Regev, Aviv et al. “The Human Cell Atlas.” eLife 2017, 6 (December 2017): e27041 © Regev et al
Version
Final published version
Abstract
The recent advent of methods for high-throughput single-cell molecular profiling has catalyzed a growing sense in the scientific community that the time is ripe to complete the 150-year-old effort to identify all cell types in the human body. The Human Cell Atlas Project is an international collaborative effort that aims to define all human cell types in terms of distinctive molecular profiles (such as gene expression profiles) and to connect this information with classical cellular descriptions (such as location and morphology). An open comprehensive reference map of the molecular state of cells in healthy human tissues would propel the systematic study of physiological states, developmental trajectories, regulatory circuitry and interactions of cells, and also provide a framework for understanding cellular dysregulation in human disease. Here we describe the idea, its potential utility, early proofs-of-concept, and some design considerations for the Human Cell Atlas, including a commitment to open data, code, and community.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Terms of Use
Creative Commons Attribution 4.0 International License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.7554/eLife.27041
