Elasticizing tissues for reversible shape transformation and accelerated molecular labeling
Name
nihms-1661109.pdf
Description
Accepted version
Size
1.43 MB
Format
Adobe PDF
Checksum (MD5)
c91147cda966ea3932fcad6fcbbc5de8
Author(s)
Ku, Taeyun
Guan, Webster
Evans, Nicholas B
Sohn, Chang Ho
Albanese, Alexandre
Kim, Joon-Goon
Frosch, Matthew P
Chung, Kwanghun
Date Issued
2020
Journal
Nature Methods
Publisher
Springer Science and Business Media LLC
Version
Author's final manuscript
Abstract
© 2020, The Author(s), under exclusive licence to Springer Nature America, Inc. We developed entangled link-augmented stretchable tissue-hydrogel (ELAST), a technology that transforms tissues into elastic hydrogels to enhance macromolecular accessibility and mechanical stability simultaneously. ELASTicized tissues are highly stretchable and compressible, which enables reversible shape transformation and faster delivery of probes into intact tissue specimens via mechanical thinning. This universal platform may facilitate rapid and scalable molecular phenotyping of large-scale biological systems, such as human organs.
MIT Department
Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Picower Institute for Learning and Memory
Massachusetts Institute of Technology. Department of Chemical Engineering
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike
Persistent DSpace Link
DOI of Published Version
10.1038/S41592-020-0823-Y
https://doi.org/10.1038/S41592-020-0823-Y
