Differential Effects of Environmental and Genetic Factors on T and B Cell Immune Traits
Name
Differential effects.pdf
Size
5.27 MB
Format
Adobe PDF
Checksum (MD5)
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Author(s)
Aguirre-Gamboa, Raul
Joosten, Irma
Urbano, Paulo C.M.
van der Molen, Renate G.
van Rijssen, Esther
van Cranenbroek, Bram
Oosting, Marije
Smeekens, Sanne
Jaeger, Martin
Zorro, Maria
Date Issued
November 2016
Journal
Cell Reports
Publisher
Elsevier
Citation
Aguirre-Gamboa, Raul et al. “Differential Effects of Environmental and Genetic Factors on T and B Cell Immune Traits.” Cell Reports 17.9 (2016): 2474–2487.
Version
Final published version
Abstract
Effective immunity requires a complex network of cellular and humoral components that interact with each other and are influenced by different environmental and host factors. We used a systems biology approach to comprehensively assess the impact of environmental and genetic factors on immune cell populations in peripheral blood, including associations with immunoglobulin concentrations, from ∼500 healthy volunteers from the Human Functional Genomics Project. Genetic heritability estimation showed that variations in T cell numbers are more strongly driven by genetic factors, while B cell counts are more environmentally influenced. Quantitative trait loci (QTL) mapping identified eight independent genomic loci associated with leukocyte count variation, including four associations with T and B cell subtypes. The QTLs identified were enriched among genome-wide association study (GWAS) SNPs reported to increase susceptibility to immune-mediated diseases. Our systems approach provides insights into cellular and humoral immune trait variability in humans.
MIT Department
Institute for Medical Engineering and Science
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/j.celrep.2016.10.053
