Design and synthesis of a new orthogonally protected glutamic acid analog and its use in the preparation of high affinity polo-like kinase 1 polo-box domain – binding peptide macrocycles
Name
d1ob01120k.pdf
Description
Published version
Size
4.25 MB
Format
Adobe PDF
Checksum (MD5)
344d78a9ca138757e7d265105024dc91
Author(s)
Hymel, David
Tsuji, Kohei
Grant, Robert A
Chingle, Ramesh M
Kunciw, Dominique L
Yaffe, Michael B
Burke, Terrence R
Date Issued
2021
Journal
Organic and Biomolecular Chemistry
Publisher
Royal Society of Chemistry (RSC)
Citation
Hymel, David, Tsuji, Kohei, Grant, Robert A, Chingle, Ramesh M, Kunciw, Dominique L et al. 2021. "Design and synthesis of a new orthogonally protected glutamic acid analog and its use in the preparation of high affinity polo-like kinase 1 polo-box domain – binding peptide macrocycles." Organic and Biomolecular Chemistry, 19 (36).
Version
Final published version
Abstract
A novel macrocyclic peptide strategy utilizing a glutamic acid analog that can work as an alkylated histidine replacement.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Terms of Use
Creative Commons Attribution NonCommercial License 4.0
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DOI of Published Version
https://doi.org/10.1039/D1OB01120K
