Magnitude and Kinetics of CD8[superscript +] T Cell Activation during Hyperacute HIV Infection Impact Viral Set Point
Name
Magnitude and kinetics of.pdf
Size
2.92 MB
Format
Adobe PDF
Checksum (MD5)
170cfdf6a1015105494f8502ff66f160
Author(s)
Ndhlovu, Zaza M.
Kamya, Philomena
Mewalal, Nikoshia
Kløverpris, Henrik N.
Nkosi, Thandeka
Pretorius, Karyn
Laher, Faatima
Ogunshola, Funsho
Chopera, Denis
Ghebremichael, Musie
Alternative Title
Magnitude and Kinetics of CD8+ T Cell Activation during Hyperacute HIV Infection Impact Viral Set Point
Date Issued
September 2015
Journal
Immunity
Publisher
Elsevier/Cell Press
Citation
Ndhlovu, Zaza M. et al. “Magnitude and Kinetics of CD8+ T Cell Activation during Hyperacute HIV Infection Impact Viral Set Point.” Immunity 43.3 (2015): 591–604.
Abstract
CD8[superscript +] T cells contribute to the control of HIV, but it is not clear whether initial immune responses modulate the viral set point. We screened high-risk uninfected women twice a week for plasma HIV RNA and identified 12 hyperacute infections. Onset of viremia elicited a massive HIV-specific CD8[superscript +] T cell response, with limited bystander activation of non-HIV memory CD8[superscript +] T cells. HIV-specific CD8[superscript +] T cells secreted little interferon-γ, underwent rapid apoptosis, and failed to upregulate the interleukin-7 receptor, known to be important for T cell survival. The rapidity to peak CD8[superscript +] T cell activation and the absolute magnitude of activation induced by the exponential rise in viremia were inversely correlated with set point viremia. These data indicate that rapid, high magnitude HIV-induced CD8[superscript +] T cell responses are crucial for subsequent immune control of acute infection, which has important implications for HIV vaccine design.
MIT Department
Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Massachusetts Institute of Technology. Department of Chemical Engineering
Ragon Institute of MGH, MIT and Harvard
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/j.immuni.2015.08.012
