Point-of-need diagnostics in a post-Covid world: an opportunity for paper-based microfluidics to serve during syndemics
Name
d4lc00699b.pdf
Description
Published version
Size
669.66 KB
Format
Adobe PDF
Checksum (MD5)
ec52210e9638868fc72ed5722744b11f
Author(s)
Tsaloglou, Maria-Nefeli
Christodouleas, Dionysios C
Milette, Jonathan
Milkey, Kendall
Romine, Isabelle C
Im, Judy
Lathwal, Shefali
Selvam, Duraipandian Thava
Sikes, Hadley D
Whitesides, George M
Date Issued
2025
Journal
Lab on a Chip
Publisher
Royal Society of Chemistry
Citation
Tsaloglou, Maria-Nefeli, Christodouleas, Dionysios C, Milette, Jonathan, Milkey, Kendall, Romine, Isabelle C et al. 2025. "Point-of-need diagnostics in a post-Covid world: an opportunity for paper-based microfluidics to serve during syndemics." Lab on a Chip, 25 (5).
Version
Final published version
Abstract
Zoonotic outbreaks present with unpredictable threats to human health, food production, biodiversity, national security and disrupt the global economy. The COVID-19 pandemic—caused by zoonotic coronavirus, SARS-CoV2— is the most recent upsurge of an increasing trend in outbreaks for the past 100 years. This year, emergence of avian influenza (H5N1) is a stark reminder of the need for national and international pandemic preparedness. Tools for threat reduction include consistent practices in reporting pandemics, and widespread availability of accurate detection technologies. Wars and extreme climate events redouble the need for fast, adaptable and affordable diagnostics at the point of need. During the recent pandemic, rapid home tests for SARS-CoV-2 proved to be a viable functional model that leverages simplicity. In this perspective, we introduce the concept of syndemnicity in the context of infectious diseases and point-of-need healthcare diagnostics. We also provide a brief state-of-the-art for paper-based microfluidics. We illustrate our arguments with a case study for detecting brucellosis in cows. Finally, we conclude with lessons learned, challenges and opportunities for paper-based microfluidics to serve point-of-need healthcare diagnostics during syndemics.
MIT Department
Massachusetts Institute of Technology. Department of Chemical Engineering
Terms of Use
Creative Commons Attribution
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1039/d4lc00699b
