Optimal design of phosphorylation-based insulation devices
Name
Del Vecchio_Optimal design.pdf
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503.7 KB
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Adobe PDF
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1c33fda1304bcb5c84598026828e9371
Author(s)
Rivera, Phillip M.
Del Vecchio, Domitilla
Date Issued
June 2013
Journal
Proceedings of the 2013 American Control Conference
Publisher
Institute of Electrical and Electronics Engineers (IEEE)
Citation
Rivera, Phillip M., and Domitilla Del Vecchio. “Optimal Design of Phosphorylation-Based Insulation Devices.” 2013 American Control Conference (June 2013).
Version
Author's final manuscript
Abstract
We seek to minimize both the retroactivity to the output and the retroactivity to the input of a phosphorylation-based insulation device by finding an optimal substrate concentration. Characterizing and improving the performance of insulation devices brings us a step closer to their successful implementation in biological circuits, and thus to modularity. Previous works have mainly focused on attenuating retroactivity effects to the output using high substrate concentrations. This, however, worsens the retroactivity to the input, creating an error that propagates back to the output. Employing singular perturbation and contraction theory tools, this work provides a framework to determine an optimal substrate concentration to reach a tradeoff between the retroactivity to the input and the retroactivity to the output.
MIT Department
Massachusetts Institute of Technology. Department of Mechanical Engineering
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1109/ACC.2013.6580416
