The Microbial Opsin Family of Optogenetic Tools
Name
Zhang-2011-The Microbial Opsin.pdf
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1.1 MB
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Author(s)
Zhang, Feng
Vierock, Johannes
Yizhar, Ofer
Fenno, Lief E.
Tsunoda, Satoshi
Kianianmomeni, Arash
Prigge, Matthias
Berndt, Andre
Cushman, John
Polle, Jürgen
Date Issued
December 2011
Journal
Cell
Publisher
Elsevier
Citation
Zhang, Feng, Johannes Vierock, Ofer Yizhar, Lief E. Fenno, Satoshi Tsunoda, Arash Kianianmomeni, Matthias Prigge, et al. “The Microbial Opsin Family of Optogenetic Tools.” Cell 147, no. 7 (December 2011): 1446–1457. © 2011 Elsevier Inc.
Version
Final published version
Abstract
The capture and utilization of light is an exquisitely evolved process. The single-component microbial opsins, although more limited than multicomponent cascades in processing, display unparalleled compactness and speed. Recent advances in understanding microbial opsins have been driven by molecular engineering for optogenetics and by comparative genomics. Here we provide a Primer on these light-activated ion channels and pumps, describe a group of opsins bridging prior categories, and explore the convergence of molecular engineering and genomic discovery for the utilization and understanding of these remarkable molecular machines.
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
McGovern Institute for Brain Research at MIT
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1016/j.cell.2011.12.004
